I

A

IRRTHUM , Alexandre

Last name: IRRTHUM

First name: Alexandre

2021 (v1)

Publication

Metadata-only

Genomic and transcriptomic analyses of breast cancer primaries and matched metastases in AURORA, the Breast International Group (BIG) molecular screening initiative

Aftimos, Philippe Oliveira, Mafalda Irrthum, Alexandre

AURORA aims to study the processes of relapse in metastatic breast cancer (MBC) by performing multi-omics profiling on paired primary tumors and early-course metastases. Among 381 patients (primary tumor and metastasis pairs: 252 TGS, 152 RNA-Seq, 67 SNP Arrays), we found a driver role for GATA1 and MEN1 somatic mutations. Metastases were...

Uploaded on: March 27, 2023