ISABELLA PANFOLI

In recent years interest in cancer metabolism has risen. A relevant role of the pentose phosphate pathway (PPP) is recognized in cancer metabolic reprogramming, involving both the cytosolic glucose-6-phosphate dehydrogenase (G6PD) and especially the less characterized endoplasmic reticulum (ER) hexose-6-phosphate dehydrogenase (H6PD). In breast...

Cancer is a complex pathology, whose burden is growing worldwide. It appears that our vision considering cancer cells as a uniform population is partial: cancer cells evolve in time, building up mutations to adapt to their environment. They become able to evade cellular controls, and then immune response. A hallmark of cancer adaptation ability...

A major challenge in biomedical science is ATP supply in the nervous system (NS). The mitochondrial Electron Transfer Chain (ETC), Fo F1 -ATP synthase and Tricarboxylic Acid (TCA) Cycle enzymes are functionally expressed outside the mitochondrion, in myelin and rod outer segments (OS). These extra-mitochondrial sites of oxidative...

Si tratta di una "Perspective", pertanto non è previsto un Abstract, sulla rilevanza della azione di modulazione della F1Fo-ATP sintasi da parte dei polifenoli, nella loro nota attività anti-cancro .

Chronic lymphocytic leukemia (CLL) is a hematological malignancy displaying a highly heterogeneous clinical course. Several studies highlight the capability of CLL B cells to control the persistent redox stress1,2 by triggering antioxidant pathways that are particularly efficient in aggressive CLL cells3. Antioxidant pathways and anabolic...