J

J. RUDNER

Last name: J. RUDNER

2010 (v1)

Publication

Metadata-only

Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.

ZOPPOLI, GABRIELE CEA, MICHELE SONCINI, DEBORA

OBJECTIVE: The nicotinamide phosphoribosyltransferase (Nampt) inhibitor APO866 depletes intracellular nicotinamide adenine dinucleotide (NAD(+)) and shows promising anticancer activity in preclinical studies. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to plasma membrane receptors DR4 and DR5 and induces apoptosis via...

Uploaded on: April 14, 2023