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JACOBY , George A.

Last name: JACOBY

First name: George A.

September 28, 2017 (v1)

Publication

Metadata-only

In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum cephalosporins

Martínez Martínez, Luis Hernández Allés, Santiago Albertí, Sebastián

Four Klebsiella pneumoniae isolates (LB1, LB2, LB3, and LB4) with increased antimicrobial resistance were obtained from the same patient. The four isolates were indistinguishable in biotype, plasmid content, lipopolysaccharide, and DNA analysis by pulse-field gel electrophoresis. Isolate LB1 made TEM-1 and SHV-1 β-lactamases. Isolates LB2, LB3,...

Uploaded on: March 27, 2023
September 28, 2017 (v1)

Publication

Metadata-only

Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae

Martínez Martínez, Luis Pascual Hernández, Álvaro Hernández Allés, Santiago

Two clinical isolates of extended-spectrum β-lactamase (ESBL)- producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of β-lactamase in resistance was investigated by eliminating the original ESBL and introducing...

Uploaded on: March 27, 2023