J

P

JAFFRES , Paul-Alain

Last name: JAFFRES

First name: Paul-Alain

April 18, 2016 (v1)

Journal article

Metadata-only

SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline

Guéguinou, Maxime Harnois, Thomas Crottes, David

Background: Barely 10-20% of patients with metastatic colorectal cancer (mCRC) receive a clinical benefit from the use of anti-EGFR monoclonal antibodies (mAbs). We hypothesized that this could depends on their efficiency to reduce Store Operated Calcium Entry (SOCE) that are known to enhance cancer cells.Results: In the present study, we...

Uploaded on: February 28, 2023