J

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JAGER , J.

Last name: JAGER

First name: J.

February 14, 2009 (v1)

Journal article

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Involvement of TNF-α in abnormal adipocyte and muscle sortilin expression in obese mice and humans

Kaddai, V. Jager, J. Gonzalez, T.

Insulin resistance is caused by numerous factors including inflammation. It is characterised by defective insulin stimulation of adipocyte and muscle glucose transport, which requires the glucose transporter GLUT4 translocation towards the plasma membrane. Defects in insulin signalling can cause insulin resistance, but alterations in GLUT4...

Uploaded on: March 10, 2024
January 2011 (v1)

Journal article

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Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.

Jager, J. Corcelle, V. Grémeaux, T.

AIMS/HYPOTHESIS: Extracellular signal-regulated kinase (ERK) activity is increased in adipose tissue in obesity and type 2 diabetes mellitus and strong evidences suggests that it is implicated in the downregulation of insulin signalling and action in the insulin-resistant state. To determine the role of ERK1 in obesity-associated insulin...

Uploaded on: December 3, 2022