Regeneration is a developmental process, which allow to regrow missing structures initially develop during embryogenesis, in response to an injury. Although, this ability to regenerate can be more or less dramatic depending on the organism, it is widely spread among metazoan. As such, suggesting a monophyletic origin and a tight link with...
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November 21, 2018 (v1)PublicationUploaded on: December 4, 2022
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November 24, 2020 (v1)Publication
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Uploaded on: December 4, 2022 -
December 2015 (v1)Journal article
Cnidarians, the extant sister group to bilateria, are well known for their impressive regenerative capacity. The sea anemone Nematostella vectensis is a well-established system for the study of development and evolution that is receiving increased attention for its regenerative capacity. Nematostella is able to regrow missing body parts within...
Uploaded on: December 4, 2022 -
May 17, 2018 (v1)Journal article
For over a century, researchers have been comparing embryogenesis and regeneration hoping that lessons learned from embryonic development will unlock hidden regenerative potential. This problem has historically been a difficult one to investigate because the best regenerative model systems are poor embryonic models and vice versa. Recently,...
Uploaded on: December 4, 2022 -
November 20, 2021 (v1)Publication
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Uploaded on: December 3, 2022 -
October 2017 (v1)Journal article
Germ layer formation and axial patterning are biological processes that are tightly linked during embryonic development of most metazoans. In addition to canonical WNT, it has been proposed that ERK-MAPK signaling is involved in specifying oral as well as aboral territories in cnidarians. However, the effector and the molecular mechanism...
Uploaded on: February 28, 2023 -
December 2016 (v1)Journal article
The nerve net of Nematostella is generated using a conserved cascade of neurogenic transcription factors. For example, NvashA, a homolog of the achaete-scute family of basic helix-loop-helix transcription factors, is necessary and sufficient to specify a subset of embryonic neurons. However, positive regulators required for the expression of...
Uploaded on: December 4, 2022 -
2017 (v1)Journal article
Epidemiological and animal studies show that deleterious maternal environments predispose aging offspring to metabolic disorders and type 2 diabetes. Young progeny in a rat model of maternal low protein diet (LP) is normoglycemic despite collapsed insulin secretion. However, without further worsening of the insulin secretion defect glucose...
Uploaded on: February 28, 2023