Using diffusion tensor imaging (DTI), it was previously found that demyelinated gray matter (GM) lesions have increased fractional anisotropy (FA) when compared to normal-appearing gray matter (NAGM) in multiple sclerosis (MS). The biological substrate underlying this FA change is so far unclear; both neurodegenerative changes and microglial...
-
2016 (v1)PublicationUploaded on: April 14, 2023
-
2015 (v1)Publication
BACKGROUND AND PURPOSE: At 7T MR imaging, T2∗-weighted gradient echo has been shown to provide high-resolution anatomic images of gray matter lesions. However, few studies have verified T2∗WI lesions histopathologically or compared them with more standard techniques at ultra-high-field strength. This study aimed to determine the sensitivity of...
Uploaded on: April 14, 2023 -
2016 (v1)Publication
Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple sclerosis. In vivo sodium magnetic resonance imaging studies have demonstrated an increase of brain total sodium concentration in patients with multiple sclerosis, especially in patients...
Uploaded on: April 14, 2023 -
2016 (v1)Publication
Background: Cortical gray matter (GM) demyelination is frequent and clinically relevant in multiple sclerosis (MS). Quantitative magnetic resonance imaging (qMRI) sequences such as magnetization transfer ratio (MTR) and quantitative R2∗ (qR2∗) can capture pathological subtleties missed by conventional magnetic resonance imaging (MRI) sequences....
Uploaded on: April 14, 2023