JOS GALLEGO , Ángeles Mencía

The cytotoxicity response of reduced graphene oxide (rGO) was investigated in monocytes (THP-1) and human T cells (Jurkat). A mean effective concentration (EC50-24 h) of 121.45 ± 11.39 μg/mL and 207.51 ± 21.67 μg/mL for cytotoxicity was obtained in THP-1 and Jurkat cells, respectively. rGO decreased THP-1 monocytes differentiation at the...

Más de 100.000 compuestos químicos están actualmente en uso, y una media de 2.000 nuevos se introducen cada año en el mercado, incluyendo compuestos industriales, plaguicidas, aditivos alimentarios, compuestos farmacéuticos, detergentes y cosméticos. Ello

Ministerio de Ciencia e Innovación PID2019-104890RB-I00, MICINN/FEDER, UE

Cylindrospermopsin (CYN) is a cyanobacterial toxin that is gaining importance, owing to its increasing expansion worldwide and the increased frequency of its blooms. CYN mainly targets the liver, but also involves other organs. Various mechanisms have been associated with its toxicity, such as protein synthesis inhibition, oxidative stress,...

Recientemente, el interés por el óxido de grafeno reducido (OGr) se ha visto incrementado debido a sus numerosas propiedades. Considerando que el uso de estos materiales ha aumentado en los últimos años, esto puede suponer un mayor riesgo para la salud humana. La vía oral es una de las principales rutas de exposición, por lo que es importante...

Microcystins (MCs) and cylindrospermopsin (CYN), although classified as hepatotoxins and cytotoxins, respectively, have been shown to also induce toxic effects in many other systems and organs. Among them, their potential endocrine disruption (ED) activity has been scarcely investigated. Considering the increasing relevance of ED on humans,...

The programme aimed at training the fellow in the risk assessment guidelines proposed by the EFSA in the field of contaminants, food contact materials, technological ingredients and nutritional risks. It had a modular 'learning by doing' approach and a balanced learning/case studies and theory. Module 1 offered an insight into chemical risk...

Different applications have been suggested for graphene nanomaterials (GFNs) in the food and feed chain. However, it is necessary to perform a risk assessment before they become market-ready, and when consumer exposure is demonstrated. For this purpose, the European Food Safety Authority (EFSA) has published a guidance that has been recently...