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JOUPPILA , Annukka S

Last name: JOUPPILA

First name: Annukka S

2023 (v1)

Publication

Metadata-only

Intravenously administered APAC, a dual AntiPlatelet AntiCoagulant, targets arterial injury site to inhibit platelet thrombus formation and tissue factor activity in mice

Bonetti, Nicole R Jouppila, Annukka S Saeedi Saravi, Seyed Soheil

Introduction: Arterial thrombosis is the main underlying mechanism of acute atherothrombosis. Combined antiplatelet and anticoagulant regimens prevent thrombosis but increase bleeding rates. Mast cell-derived heparin proteoglycans have local antithrombotic properties, and their semisynthetic dual AntiPlatelet and AntiCoagulant (APAC) mimetic...

Uploaded on: August 29, 2024