JUAN , Thomas

The proper establishment of Left/Right (L/R) asymmetry is fundamental to normal development in bilaterians. However, the initial mechanisms involved in symmetry breaking and their conservation throughout the course of evolution remain poorly understood. In zebrafish, the L/R organizer region or Kupffer's vesicle (KV) consists as a fluid filled...

Since its discovery more than 50 years ago, the endo-lysosomal system has emerged as a central integrator of different cellular activities. This vesicular trafficking apparatus governs processes as diverse as the transduction of stimuli by growth factor receptors, the recycling and secretion of signaling molecules and the regulation of cellular...