JUGE , Nathalie

Last name: JUGE

First name: Nathalie

June 9, 2020 (v1)

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Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

Owen, C. David Tailford, Louise E. Monaco, Serena

Ruminococcus gnavus is a human gut symbiont wherein the ability to degrade mucins is mediated by an intramolecular trans-sialidase (RgNanH). RgNanH comprises a GH33 catalytic domain and a sialic acid-binding carbohydrate-binding module (CBM40). Here we used glycan arrays, STD NMR, X-ray crystallography, mutagenesis and binding assays to...

Uploaded on: December 4, 2022
December 14, 2020 (v1)

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Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria

Bell, Andrew Severi, Emmanuele Lee, Micah

The human gut symbiont Ruminococcus gnavus scavenges host-derived N-acetylneuraminic acid (Neu5Ac) from mucins by converting it to 2,7-anhydro-Neu5Ac. We previously showed that 2,7-anhydro-Neu5Ac is transported into R. gnavus ATCC 29149 before being converted back to Neu5Ac for further metabolic processing. However, the molecular mechanism...

Uploaded on: December 4, 2022
January 21, 2022 (v1)

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The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

Wu, H. Crost, E. Owen, C. David

AU The:human Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly gut symbiont Ruminococcus gnavus displays strain-specific : repertoires of glycoside hydrolases (GHs) contributing to its spatial location in the gut. Sequence similarity network analysis identified strain-specific differences in blood-group endo-β-1,4-galactosidase belonging...

Uploaded on: March 25, 2023

JUGE , Nathalie

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