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KARSAI , Gergely

Last name: KARSAI

First name: Gergely

2024 (v1)

Publication

Metadata-only

Inhibition of de novo ceramide synthesis by Sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes

Velagapudi, Srividya Karsai, Gergely Karsai, Maria

Background: Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular diseases (CVD). Dysregulated pro-apoptotic ceramide synthesis reduces β-cell insulin secretion, thereby promoting hyperglycemic states which may manifest as T2D. Pro-apoptotic ceramides modulate insulin sensitivity and glucose tolerance while being linked to...

Uploaded on: July 3, 2024
January 2022 (v1)

Journal article

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Discovery and mechanism of action of small molecule inhibitors of ceramidases

Healey, Robert Saied, Essa Cong, Xiaojing

Sphingolipid metabolism is tightly controlled by enzymes to regulate essential processes in human physiology. The central metabolite is ceramide, a pro-apoptotic lipid catabolized by ceramidase enzymes to produce pro-proliferative sphingosine-1phosphate. Alkaline ceramidases are transmembrane enzymes that recently attracted attention for drug...

Uploaded on: December 4, 2022