KAYATEKIN , Mete

Gamma-glutamyl dipeptides are yielded by the condensation of glutamate with another amino acid on the gamma position. Their synthesis results from the hydrolysis of glutathione (GSH ; gamma-Glu-Cys-Gly) by gamma- glutamyl transferase (GGT). In fact, while g-glutamyl dipeptides have been detected in different organs and fluids of the body,...

Deposition of monosodium urate and calcium pyrophosphate (MSU and CPP) micro-crystals is responsible for painful and recurrent inflammation flares in gout and chondrocalcinosis. In these pathologies, the inflammatory reactions are due to the activation of macrophages responsible for releasing various cytokines including IL-1β. The maturation of...