Dax-1 (Nr0b1) is an orphan member of the nuclear hormone receptor superfamily that has a key role in adrenogonadal development and function. Recent studies have also implicated Dax-1 in the transcriptional network controlling embryonic stem (ES) cell pluripotency. Here, we show that Dax-1 expression is affected by differentiating treatments and...
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July 2009 (v1)Journal articleUploaded on: December 3, 2022
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October 2021 (v1)Journal article
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Uploaded on: December 3, 2022 -
February 17, 2020 (v1)Journal article
Background: Leptin is potentially involved in the correction of early postnatal growth of infants having deviated from their genetic trajectory in utero.Aim: To analyse the potential mediating role of cord blood leptin level in the association between neonatal anthropometry and early postnatal growth in the mother-child EDEN cohort.Subjects and...
Uploaded on: December 4, 2022 -
2020 (v1)Journal article
Nearly 10% of 5-year-old children experience social, emotional or behavioral problems and are at increased risk of developing mental disorders later in life. While animal and human studies have demonstrated that cytokines can regulate brain functions, it is unclear whether individual cytokines are associated with specific behavioral dimensions...
Uploaded on: December 4, 2022 -
October 2020 (v1)Journal article
Disruption of neurodevelopmental trajectories can alter brain circuitry and increase the risk of psychopathology later in life. While preclinical studies have demonstrated that the immune system and cytokines influence neu-rodevelopment, whether immune activity and in particular which cytokines at birth are associated with psy-chopathology...
Uploaded on: December 4, 2022 -
July 2023 (v1)Journal article
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Uploaded on: October 13, 2023 -
February 2017 (v1)Journal article
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Uploaded on: December 4, 2022 -
July 15, 2023 (v1)Journal article
Childhood internalizing disorders refer to inwardly focused negative behaviours such as anxiety, depression, and somatic complains. Interactions between psychosocial, genetic, and environmental risk factors adversely impact neurodevelopment and can contribute to internalizing disorders. While prenatal exposure to single endocrine disruptors...
Uploaded on: December 20, 2023 -
February 1, 2009 (v1)Journal article
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May 2022 (v1)Journal article
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March 2013 (v1)Journal article
The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1 gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of inherited intellectual disability. FXR1P plays an important role in normal muscle development, and its absence causes muscular abnormalities in mice, frog, and zebrafish. Seven...
Uploaded on: December 2, 2022 -
March 2013 (v1)Journal article
The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1 gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of inherited intellectual disability. FXR1P plays an important role in normal muscle development, and its absence causes muscular abnormalities in mice, frog, and zebrafish. Seven...
Uploaded on: October 11, 2023 -
2022 (v1)Journal article
Background: Cord blood leptin is an indicator of neonatal fat mass and could shape postnatal adiposity trajectories. Investigating genetic polymorphisms of the leptin receptor gene (LEPR) could help understand the mechanisms involved.Objectives: We aimed to investigate the association of cord blood leptin level and the LEPR rs9436303...
Uploaded on: December 3, 2022 -
April 15, 2020 (v1)Journal article
Background: Fragile X syndrome (FXS) is the most frequent cause of inherited intellectual disability and the most commonly identified monogenic cause of autism. Recent studies have shown that long-term pathological consequences of FXS are not solely confined to the central nervous system (CNS) but rather extend to other physiological...
Uploaded on: December 4, 2022 -
July 2024 (v1)Journal article
There is growing evidence that in utero imbalance immune activity plays a role in the development of neurodevelopmental and psychiatric disorders in children. Mood dysregulation (MD) is a debilitating transnosographic syndrome whose underlying pathophysiological mechanisms could be revealed by studying its biomarkers using the Research Domain...
Uploaded on: July 10, 2024 -
August 2023 (v1)Journal article
Abstract Neuroinflammation has been proposed to impact symptomatology in patients with schizophrenia spectrum disorders. While previous studies have shown equivocal effects of treatments with add-on anti-inflammatory drugs such as Aspirin, N -acetylcysteine and Celecoxib, none have used a subset of prospectively recruited patients exhibiting an...
Uploaded on: October 13, 2023 -
July 14, 2021 (v1)Journal article
Abstract Background Patients with a First-Episode of Psychosis (FEP) exhibit low-grade inflammation as demonstrated by elevated levels of C reactive protein (CRP) and pro-inflammatory cytokines. Aims The primary goal of this study was to investigate the association between pro-inflammatory biomarkers and clinical outcomes in unmedicated FEP...
Uploaded on: December 4, 2022 -
December 2019 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
December 2019 (v1)Journal article
Early response to first-line antipsychotic treatments is strongly associated with positive long-term symptomatic and functional outcome in psychosis. Unfortunately, attempts to identify reliable predictors of treatment response in firstepisode psychosis (FEP) patients have not yet been successful. One reason for this could be that FEP patients...
Uploaded on: December 4, 2022