KHOUBZA , Lamyaa

Of the various potassium channel families, the two-pore domain potassium channel family, K2P, is the latest to be discovered at IPMC. These channels are responsible for the so-called "background" currents which maintains negative membrane potential thus reducing cell excitability. Many physiological functions depend on these channels...

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International audience

International audience

International audience

Two-pore domain K+ channels (K2P channels), active as dimers, produce inhibitory currents regulated by a variety of stimuli. Among them, TWIK1-related alkalinization-activated K+ channel 1 (TALK1), TWIK1-related alkalinization-activated K+ channel 2 (TALK2), and TWIK1-related acid-sensitive K+ channel 2 (TASK2) form a subfamily of structurally...

Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here, we reveal the conserved role played by a single amino acid position (TM2.6) located in the second transmembrane domain of two-pore domain potassium (K2P) channels. Mutations of TM2.6 to aspartate...