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KIESS , Wieland

Last name: KIESS

First name: Wieland

2019 (v1)

Publication

Metadata-only

The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells

Kirstein, Anna S Augustin, Adrien Penke, Melanie

Germline mutations in the tumor suppressor gene PTEN cause PTEN Hamartoma Tumor Syndrome (PHTS). Pediatric patients with PHTS frequently develop lipomas. Treatment attempts with the mTORC1 inhibitor rapamycin were unable to reverse lipoma growth. Recently, lipomas associated with PIK3CA-related overgrowth syndrome were successfully treated with...

Uploaded on: April 14, 2023
2015 (v1)

Publication

Metadata-only

De novo loss-or gain-of-function mutations in KCNA2 cause epileptic encephalopathy

Syrbe, Steffen Hedrich, Ulrike B. S. Riesch, Erik

No description

Uploaded on: May 13, 2023