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KIND , Michèle

Last name: KIND

First name: Michèle

September 2019 (v1)

Journal article

Metadata-only

Pazopanib or methotrexate–vinblastine combination chemotherapy in adult patients with progressive desmoid tumours (DESMOPAZ): a non-comparative, randomised, open-label, multicentre, phase 2 study

Toulmonde, Maud Pulido, Marina Ray-Coquard, Isabelle

Background: Desmoid tumours are locally aggressive tumours associated with substantial morbidity. No systemic treatments are approved for this disease, with methotrexate-vinblastine the only chemotherapy regimen assessed in a clinical trial setting to date. VEGF overexpression is a common feature in aggressive desmoid tumours. Pazopanib is an...

Uploaded on: December 3, 2022
April 8, 2022 (v1)

Publication

Metadata-only

Abstract 2578: High regulatory T cells infiltrate within tertiary lymphoid structure restricts response to immune checkpoint blockers in sarcomas

Peyraud, Florent Guegan, Jean-Philippe Rey, Christophe

Abstract Background: While composition of the tumor microenvironment (TME) is a prerequisite for an effective antitumor immunity, infiltration of organized B- and T-cells aggregates called tertiary lymphoid structures (TLS) has been recently demonstrated to predict response to immune checkpoint blockers (ICB) in sarcomas. However, only a...

Uploaded on: September 12, 2024