KLEMAN , Patryk Artur

The asymmetric hydrogenation of prochiral enamides with Rh complexes bearing chiral phosphine–phosphite ligands (P–OP) supported on sulphonated polystyrene resins has been studied. The complexes have been supported by simple treatment of preformed [Rh(diolefin)(P–OP)](BF4) with the Li salt of resins. In MeOH, high enantioselectivities were...

The enantioselective catalytic hydrogenation of N-(3,4-dihydronaphthalen-2- yl) amides (1) with rhodium catalysts bearing phosphine-phosphite ligands 4 has been studied. A wide catalyst screening, facilitated by the modular structure of 4, has found a highly enantioselective catalyst for this reaction. This catalyst gives a 93% ee in the...

The enantioselective hydrogenation of enol esters of formula CH2=C(OBz)R with rhodium catalysts based on phosphine-phosphite ligands (P-OP) has been studied. The reaction has a broad scope and it is suitable for the preparation of products possessing a wide variety of R substituents. For the cases where R is a primary alkyl high catalyst...

Going chiral! Highly enantioselective catalytic hydrogenations of enol esters 1 by using a Rh catalyst bearing a POP ligand are described (see scheme; NBD=norbornadiene). The catalytic system has a broad scope and allows the preparation of a wide range of chiral esters 2 bearing diverse alkyls or a benzyl group with high...

Phosphine-phosphites 3a and 3b, derived from diphenylhydroxymethyl phosphine have been prepared. From these ligands [Rh(COD)(3a)]BF4 5a and RuCl2(3b)[(S,S)-DPEN] 6b (DPEN = 1,2-diphenylethylenediamine) were synthesized and their structure determined by X-ray diffraction. Ligands 3 are characterized by a small bite angle of 83°. In addition, 5a...