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KORDOWICH , Simon

Last name: KORDOWICH

First name: Simon

December 2012 (v1)

Journal article

Metadata-only

Generation of animals allowing the conditional inactivation of the Pax4 gene.

Kordowich, Simon Serup, Palle Collombat, Patrick

Pax4 belongs to the paired-box family of transcription factors. The analysis of loss- and gain-of-function mutant animals revealed that this factor plays a crucial role in the endocrine pancreas. Indeed, Pax4 is required for the genesis of insulin-producing beta-cells. Remarkably, the sole misexpression of Pax4 in glucagon-expressing cells is...

Uploaded on: December 3, 2022
August 31, 2011 (v1)

Journal article

Metadata-only

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.

Kordowich, Simon Collombat, Patrick Mansouri, Ahmed

ABSTRACT: BACKGROUND: Nkx2.2 and Arx represent key transcription factors implicated in the specification of islet cell subtypes during pancreas development. Mice deficient for Arx do not develop any alpha-cells whereas beta- and delta-cells are found in considerably higher numbers. In Nkx2.2 mutant animals, alpha- and beta-cell development is...

Uploaded on: December 3, 2022