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KUGEMANN , Andreas

Last name: KUGEMANN

First name: Andreas

2018 (v1)

Publication

Metadata-only

Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2

Kirsch, Sonja A. Kugemann, Andreas Carpaneto, Armando

Mammalian two-pore channels (TPCs) are activated by the low-abundance membrane lipid phosphatidyl-(3,5)-bisphosphate (PI(3,5)P2) present in the endo-lysosomal system. Malfunction of human TPC1 or TPC2 (hTPC) results in severe organellar storage diseases and membrane trafficking defects. Here, we compared the lipid-binding characteristics of...

Uploaded on: April 14, 2023