KURZENNE , Jean-Yves

Skeletal muscle cells constitute a heterogeneous population which maintains muscle integrity through a high myogenic regenerative capacity. More unexpectedly this population is also endowed with an adipogenic potential, even in humans, and intra-muscular adipocytes have been found to be present in several disorders. We tested the distribution...

Here, we report the isolation of a human multipotent adipose-derived stem (hMADS) cell population from adipose tissue of young donors. hMADS cells display normal karyotype; have active telomerase; proliferate >200 population doublings; and differentiate into adipocytes, osteoblasts, and myoblasts. Flow cytometry analysis indicates that hMADS...

The differentiation of multipotent cells into undesirable lineages is a significant risk factor when performing cell therapy. In muscular diseases, myofiber loss can be associated with progressive fat accumulation that is one of the primary factors leading to decline of muscular strength. Therefore, to avoid any contribution of injected...