La mitocondria es uno de los principales moduladores de los niveles de calcio citosólico además de la principal fuente de energía de la célula. De particular importancia es el papel que tiene en células polarizadas como las neuronas. La correcta regulación espacio-temporal del proceso de neurotransmisión depende de la señalización por calcio....
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December 12, 2019 (v1)PublicationUploaded on: March 26, 2023
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May 11, 2023 (v1)Publication
Spinal muscular atrophy (SMA) is the most frequent genetic cause of infant mortality. The disease is characterized by progressive muscle weakness and paralysis of axial and proximal limb muscles. It is caused by homozygous loss or mutation of the SMN1 gene, which codes for the Survival Motor Neuron (SMN) protein. In mouse models of the...
Uploaded on: May 13, 2023 -
April 13, 2023 (v1)Publication
Presynaptic Ca2+ regulation is critical for accurate neurotransmitter release, vesicle reloading of release sites, and plastic changes in response to electrical activity. One of the main players in the regulation of cytosolic Ca2+ in nerve terminals is mitochondria, which control the size and spread of the Ca2+ wave during sustained electrical...
Uploaded on: April 15, 2023 -
January 10, 2023 (v1)Publication
Spinal muscular atrophy (SMA) is an autosomal recessive degenerative motor neuron disease characterized by symmetrical muscle weakness and atrophy of limb and trunk muscles being the most severe genetic disease in children. In SMA mouse models, motor nerve terminals display neurotransmitter release reduction, endocytosis decrease and...
Uploaded on: March 24, 2023 -
April 4, 2023 (v1)Publication
The neuromuscular junction (NMJ) is the peripheral synapse that controls the coordinated movement of many organisms. The NMJ is also an archetypical model to study synaptic morphology and function. As the NMJ is the primary target of neuromuscular diseases and traumatic injuries, the establishment of suitable models to study the contribution of...
Uploaded on: April 14, 2023