LÓPEZ MARQUÉS , Rosa Laura

El pirofosfato (PPi) es una sencilla molécula inorgánica que posee un enlace P-O-P, denominado enlace pirofosfato, caracterizado por su elevada energía libre de hidrólisis. Esta molécula se genera como subproducto en un gran número de reacciones anabólicas. Hasta hace poco, se pensaba que el PPi era hidrolizado únicamente por las pirofosfatas...

Soluble and membrane-bound inorganic pyrophosphatases (sPPase and H -PPase, respectively) of the purple nonsulfur bacterium Rhodospirillum rubrum are differentially regulated by environmental growth conditions. Both proteins and their transcripts were found in cells of anaerobic phototrophic batch cultures along all growth phases, although they...

An increasing body of biochemical and genetic evidence suggests that inorganic pyrophosphate (PPi) plays an important role in protist bioenergetics. In these organisms, two types of inorganic pyrophosphatases [EC 3.6.1.1, namely soluble PPases (sPPases) and proton-translocating PPases (H+-PPases)] that hydrolyse the PPi generated by cell...

Two types of proteins that hydrolyze inorganic pyrophosphate (PPi), very different in both amino acid sequence and structure, have been characterized to date: soluble and membrane-bound proton-pumping pyrophosphatases (sPPases and H+-PPases, respectively). sPPases are ubiquitous proteins that hydrolyze PPi releasing heat, whereas H+-PPases, so...