2010 (v1)
Publication
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2010 (v1)Publication
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2009 (v1)Publication
PURPOSE. The anterior chamber of the eye is a highly specialized structure delimited by the cornea, lens, and iris. It contains the aqueous humor, secreted by the ciliary body and drained by the trabecular meshwork. Alteration of aqueous humor homeostasis plays a major role in the pathogenesis of glaucoma. The trabecular meshwork is the target...
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2011 (v1)Publication
Open-angle glaucoma appears to be induced by the malfunction of the trabecular meshwork cells due to injury induced by oxidative damage and mitochondrial impairment. Here, we report that, in fact, we have detected mitochondrial damage only in primary open-angle glaucoma and pseudo-exfoliation glaucoma, among several glaucoma types...
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2011 (v1)Publication
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2004 (v1)Publication
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2010 (v1)Publication
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2015 (v1)Publication
Oxidative stress plays an important role in glaucoma. Some preservatives of anti-glaucoma drugs, commonly used in glaucoma therapy, can prevent or induce oxidative stress in the trabecular meshwork. The aim of this study is to evaluate cellular and molecular damage induced in trabecular meshwork by preservatives contained in anti-glaucoma...
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2002 (v1)Publication
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2003 (v1)Publication
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2004 (v1)Publication
We previously showed that sunlight-mimicking light induces genotoxic damage not only in skin but also even in lung, bone marrow, and peripheral blood of hairless mice. Moreover, light and smoke acted synergically in the respiratory tract. To clarify the mechanisms involved, we investigated by cDNA-arrays the expression of 746 toxicologically...
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2003 (v1)Publication
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2012 (v1)Publication
Dysregulation of microRNAs (miRNAs) has important consequences on gene and protein expression since a single miRNA targets a number of genes simultaneously. This article provides a review of published data and ongoing studies regarding the effects of cigarette smoke (CS), either mainstream (MCS) or environmental (ECS), on the expression of...
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2004 (v1)Publication
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2010 (v1)Publication
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2011 (v1)Publication
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2004 (v1)Publication
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Uploaded on: March 25, 2023 -
2004 (v1)Publication
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2010 (v1)Publication
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2005 (v1)Publication
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2012 (v1)Publication
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2001 (v1)Publication
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2005 (v1)Publication
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2013 (v1)Publication
The broad application of nanotechnology in medicine, biology, and pharmacology is leading to a dramatic increase of the risk of direct contact of nanoproducts, among which gold nanoparticles (AuNP), with the human organism. The present study aimed at evaluating in vivo the genotoxicity of AuNPs with average size of 40. nm and 100. nm. A single...
Uploaded on: July 3, 2024