2009 (v1)
Publication
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Uploaded on: March 31, 2023
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Last name: LUZZI
First name: Paola
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The in vitro effects of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR, fenretinide) on primary B-cell chronic lymphocytic leukemia (CLL) cells from previously untreated CLL patients were investigated. 4HPR promoted the intrinsic apoptotic pathway by ROS generation and was accompanied by drop of Mcl-1 protein expression. The latter...