LABRADOR GARRIDO , Adahir

This Doctoral Thesis is focused on the interplay between the immune system and the Parkinson's related protein alpha-Synuclein. The first part of this work was to study the impact of extracellular aSyn priming on the microglial innate immune response following TLR stimulation. As a result we found that extracellular non-aggregated...

Las HSPs (chaperonas o proteínas de choque térmico ('heat-shock proteins' o HSPs)) poseen dos características muy valiosas que podrían ser explotadas productivamente y de forma específica para una manipulación 'inteligente' de la respuesta inmunitaria para tratar trastornos 'conformacionales' o 'proteinopatías': sus funciones clásicas de...

The formation of misfolded protein oligomers during early stages of amyloid aggregation and the activation of neuroinflammatory responses are two key events associated with neurodegenerative diseases. Although it has been established that misfolded oligomers are involved in the neuroinflammatory process, the links between their structural...

α-Synuclein (αSyn) is a 140-residue amyloid-forming protein whose aggregation is linked to Parkinson's disease (PD). It has also been found to play a critical role in the immune imbalance that accompanies disease progression, a characteristic that has prompted the search for an effective αSyn-based immunotherapy. In this study, we have...

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In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, which accompanies the development of Parkinson's disease and other related disorders, such as Dementia with Lewy Bodies and Alzheimer's disease. Nevertheless, the cellular and molecular mechanisms underlying its...

Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded α-synuclein (αSyn) protein, is known to contribute to the pathophysiology of Parkinson's disease (PD). In this work, based on the immunomodulatory activities displayed by particular heat-shock proteins (HSPs), we tested a novel...