Pain is a main trigger for a patient to visit a physician. Those with chronic joint pain represent a large population seeking medical care and pain relief. The problematic is that analgesic treatments prescribed today are disappointing, mainly because the pathophysiology remains poorly understood. Improving patient care by discovering new...
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February 11, 2022 (v1)PublicationUploaded on: December 3, 2022
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2023 (v1)Journal article
Objective Intercellular communication within pancreatic ductal adenocarcinoma (PDAC) dramatically contributes to metastatic processes. The underlying mechanisms are poorly understood, resulting in a lack of targeted therapy to counteract stromal-induced cancer cell aggressiveness. Here, we investigated whether ion channels, which remain...
Uploaded on: November 25, 2023 -
2022 (v1)Journal article
Abstract Rheumatic diseases are often associated to debilitating chronic pain, which remains difficult to treat and requires new therapeutic strategies. We had previously identified lysophosphatidylcholine (LPC) in the synovial fluids from few patients and shown its effect as a positive modulator of acid-sensing ion channel 3 (ASIC3) able to...
Uploaded on: November 25, 2023 -
2022 (v1)Journal article
International audience
Uploaded on: December 3, 2022 -
November 25, 2021 (v1)Publication
Rheumatic diseases are often associated to debilitating chronic joint pain, which remains difficult to treat and requires new therapeutic strategies. Here, we describe increased content of lysophosphatidyl-choline (LPC) 16:0 in the knee synovial fluids of two independent cohorts of patients with painful joint diseases. If LPC16:0 levels...
Uploaded on: December 3, 2022 -
October 27, 2022 (v1)Journal article
Abstract Rheumatic diseases are often associated to debilitating chronic pain, which remains difficult to treat and requires new therapeutic strategies. We had previously identified lysophosphatidylcholine (LPC) in the synovial fluids from few patients and shown its effect as a positive modulator of acid-sensing ion channel 3 (ASIC3) able to...
Uploaded on: December 7, 2023 -
2022 (v1)Journal article
Rheumatic diseases are often associated to debilitating chronic pain, which remains difficult to treat and requires new therapeutic strategies. We had previously identified lysophosphatidylcholine (LPC) in the synovial fluids from few patients and shown its effect as a positive modulator of acid-sensing ion channel 3 (ASIC3) able to induce...
Uploaded on: December 8, 2023 -
2022 (v1)Journal article
International audience
Uploaded on: December 3, 2022 -
2022 (v1)Journal article
Several bone conditions, eg, bone cancer, osteoporosis, and rheumatoid arthritis (RA), are associated with a risk of developing persistent pain. Increased osteoclast activity is often the hallmark of these bony pathologies and not only leads to bone remodeling but is also a source of pronociceptive factors that sensitize the bone-innervating...
Uploaded on: April 14, 2023 -
2022 (v1)Journal article
Several bone conditions, eg, bone cancer, osteoporosis, and rheumatoid arthritis (RA), are associated with a risk of developing persistent pain. Increased osteoclast activity is often the hallmark of these bony pathologies and not only leads to bone remodeling but is also a source of pronociceptive factors that sensitize the bone-innervating...
Uploaded on: December 8, 2023