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Last name: LALIS
First name: Maxence
International audience
International audience
Understanding how chemicals code for a certain type of taste is fundamental for the development of a rational method to create new taste modulators. The identification of these new candidates is important for the food industry and would also be beneficial for the pharmacology industry. In humans, the bitter taste depends on a large family of 25...
Odorant-binding proteins (OBPs) are abundant soluble proteins secreted in the nasal mucus of a variety of species which are believed to be involved in the transport of odorants towards olfactory receptors. In this study, we report the functional characterization of mouse OBP5 (mOBP5). mOBP5 was recombinantly expressed as a hexahistidine-tagged...
Odorant-binding proteins are soluble proteins abundantly secreted in the nasal mucus of vertebrates. Although their physiological functions are not known, these proteins are suspected to have a carrier role in solubilizing and carrying hydrophobic odorant molecules to the olfactory receptors. Here, we describe the expression of functional mouse...
Mammalian sense of smell is triggered by interaction between odorant molecules and a class of proteins, called olfactory receptors (ORs). These receptors, expressed at the surface of olfactory sensory neurons, encode myriad of distinct odors via a sophisticated activation pattern. However, determining the molecular recognition spectrum of ORs...
The mechanisms of odor discrimination are based on the differential interactions of odorant molecules with olfactory receptors (ORs). The biohybrid sensors described so far using ORs show selectivity towards specific versus non-specific binding. Here we disclose a method that enables odorant discrimination based on modulation of the capacitive...
Olfactory perception begins when odorous substances interact with specialized receptors located on the surface of dedicated sensory neurons. The recognition of smells depends on a complex mechanism involving a combination of interactions between an odorant and a set of odorant receptors (ORs), where molecules are recognized according to a...
Over the past two decades, the use of odorant-binding proteins (OBPs) for the development of biosensors and bioelectronic noses (bioeNs) aimed at detecting and analyzing volatile organic compounds (VOCs) has been the subject of considerable research. However, there is a lack of fundamental studies for better understanding the interaction...