The major form of membranous nephropathy is characterized by autoantibodies to phospholipase A2 receptor 1 (PLA2R1). The study by Tomas et al. describes the first animal model where human PLA2R1 is ectopically expressed in mouse podocytes. Intriguingly, the transgenic mice spontaneously develop anti-human PLA2R1 antibodies and membranous...
-
2023 (v1)Journal articleUploaded on: October 13, 2023
-
2008 (v1)Journal article
Phospholipases A(2) (PLA2s) are esterases that hydrolyze the sn-2 ester of glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes. The mammalian genome contains 10 enzymatically active secreted PLA2s (sPLA2s) and two sPLA2-related proteins devoid of lipolytic enzymatic activity. In addition to the...
Uploaded on: December 4, 2022 -
November 23, 2010 (v1)Journal article
International audience
Uploaded on: December 3, 2022 -
January 15, 2024 (v1)Publication
International audience
Uploaded on: January 19, 2024 -
October 2021 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
March 30, 2007 (v1)Journal article
Secreted phospholipases A(2) (sPLA(2)s) represent a new class of human immunodeficiency virus (HIV) inhibitors that block the early steps of virus entry into cells. Here, we applied an in vitro evolution/selection procedure to select, from primary HIV isolates, an emerging variant (HIV(RBV-3)) able to actively infect cells in the presence of...
Uploaded on: February 28, 2023 -
June 2010 (v1)Journal article
Among the emerging phospholipase A(2) (PLA(2)) superfamily, the secreted PLA(2) (sPLA(2)) family consists of low-molecular-mass, Ca(2+)-requiring extracellular enzymes with a His-Asp catalytic dyad. To date, more than 10 sPLA(2) enzymes have been identified in mammals. Individual sPLA(2)s exhibit unique tissue and cellular localizations and...
Uploaded on: December 3, 2022 -
April 2012 (v1)Journal article
Neuroinflammation, which is one of the hallmarks of neurodegenerative disorders such as Alzheimer's disease, involves secretion of pro-inflammatory mediators by activated glial cells. Secreted phospholipase A(2) group IIA (sPLA(2)IIA) has been implicated as an inflammatory mediator contributing to various peripheral inflammatory conditions;...
Uploaded on: December 4, 2022 -
December 15, 2011 (v1)Journal article
Human group IIA-secreted phospholipase A(2) (sPLA(2)-IIA) is a bactericidal molecule important for the innate immune defense against Gram-positive bacteria. In this study, we analyzed its role in the host defense against Streptococcus pyogenes, a major human pathogen, and demonstrated that this bacterium has evolved a previously unidentified...
Uploaded on: December 3, 2022 -
January 2006 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
January 2006 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
December 15, 2013 (v1)Journal article
Group B streptococcus (GBS) is a leading neonatal pathogen and a growing cause of invasive disease in the elderly, with clinical manifestations such as pneumonia and sepsis. Despite its clinical importance, little is known about innate immunity against GBS in humans. Here, we analyze the role of human group IIA secreted phospholipase A2...
Uploaded on: December 4, 2022 -
March 2009 (v1)Journal article
Senescence is a stable proliferative arrest induced by various stresses such as telomere erosion, oncogenic or oxidative stress. Compelling evidence suggests that it acts as a barrier against tumour development. Describing new mechanisms that favour an escape from senescence can thus reveal new insights into tumorigenesis. To identify new genes...
Uploaded on: December 3, 2022 -
November 16, 2006 (v1)Journal article
A collection of 2150 druggable active sites from the Protein Data Bank was screened by high-throughput docking to identify putative targets for five representative molecules of a combinatorial library sharing a 1,3,5-triazepan-2,6-dione scaffold. Five targets were prioritized for experimental evaluation by computing enrichment in individual...
Uploaded on: February 28, 2023 -
November 2019 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
2005 (v1)Journal article
Anthrax is an acute disease caused by Bacillus anthracis. Some animal species are relatively resistant to anthrax infection. This trait has been correlated to the extent of the local inflammatory reaction, suggesting innate immunity to be the first line of defense against B. anthracis infection in nonimmunized hosts. Group IIA secreted...
Uploaded on: December 4, 2022 -
October 2021 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
2009 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
August 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
April 29, 2010 (v1)Journal article
Secreted phospholipases A2 (sPLA2s) are present in atherosclerotic plaques and are now considered novel attractive therapeutic targets and potential biomarkers as they contribute to the development of atherosclerosis through lipoprotein-dependent and independent mechanisms. We have previously shown that hGX-sPLA2-phospholipolyzed LDL (LDL-X)...
Uploaded on: December 3, 2022