LAMBERT , Jean-Charles

CIGALE∗ means Code Investigating GALaxy Emission. This open-source code is developed in Python 3 and parallelized. It is built to study the evolution of galaxies by statistically comparing modelled galaxy Spectral Energy Distributions (SEDs) to observed ones. CIGALE can handle data from the X-rays and far ultraviolet to the far infrared and...

La maladie d'Alzheimer est une véritable pathologieet non un simple effet du vieillissement même si ellese révèle, le plus souvent, aux âges avancés de la vie.La détérioration progressive intellectuelle et physiqueassociée à cette maladie est douloureusement ressentiepar les proches qui accompagnent au quotidienle patient. Les différentes...

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found...

Abstract Morphological alterations of the endosomal compartment have been widely described in post-mortem brains from Alzheimer's disease (AD) patients and subjects with Down syndrome (DS) who are at high risk for AD. Immunostaining with antibodies against endosomal markers such as Early Endosome Antigen 1 (EEA1) revealed increased size of...