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2024 (v1)PublicationUploaded on: February 23, 2024
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2021 (v1)Publication
The Staudinger synthesis of β-lactams from imines and ketenes has been conducted photochemically only in very limited cases. Recent advances in the visible light mediated Wolff rearrangement of diazoketones allowed us to perform, for the first time, a 3-component Staudinger reaction, by mixing aldehydes, amines and diazoketones in the dark and...
Uploaded on: April 14, 2023 -
2022 (v1)Publication
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Uploaded on: February 14, 2024 -
2021 (v1)Publication
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Uploaded on: February 14, 2024 -
2022 (v1)Publication
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Uploaded on: February 14, 2024 -
2012 (v1)Publication
Fragment-based methods have emerged in the last two decades as alternatives to traditional high throughput screenings for the identification of chemical starting points in drug discovery. One arguable yet popular assumption about fragment-based design is that the fragment binding mode remains conserved upon chemical expansion. For instance, the...
Uploaded on: March 27, 2023 -
2017 (v1)Publication
Chiral, enantiopure 1,3-amino alcohols, obtained through an organocatalytic Mannich reaction, have been used as starting materials for a concise sequence involving a diastereoselective Ugi reaction followed by various types of SN2 cyclization. In this way, different enantiopure heterocycles have been prepared, with both scaffold and decoration...
Uploaded on: April 14, 2023 -
2018 (v1)Publication
The increasing use of gold nanoparticles (AuNPs), especially in biomedical applications, requires strict chemico-physical characteristics achievable by organic functionalization via ligand – exchange process. Nowadays, one of the most common synthetic procedures to obtain small and hydrophilic AuNPs consists on the synthesis of 1-Dodecanethiol...
Uploaded on: April 14, 2023 -
2022 (v1)Publication
The carbocatalyzed synthesis of 2,3-disubstituted quinolines is disclosed. This process involved a three-component Povarov reaction of anilines, aldehydes and electron-enriched enol ethers, which gave the substrate for the subsequent oxidation. Graphene oxide (GO) was exploited as a heterogeneous, metal-free and sustainable catalyst for both...
Uploaded on: February 4, 2024 -
2013 (v1)Publication
Despite the recognized importance of membrane proteins as pharmaceutical targets, the reliable identification of fragment hits that are able to bind these proteins is still a major challenge. Among different 19F NMR spectroscopic methods, n-fluorine atoms for biochemical screening (n-FABS) is a highly sensitive technique that has been used...
Uploaded on: April 14, 2023 -
2014 (v1)Publication
The possibility of measuring the action of inhibitors of specific enzymatic reactions in intact cells, cell lysates or membrane preparations represents a major advance in the lead discovery process. Despite the relevance of assaying in physiological conditions, only a small number of biophysical techniques, often requiring complex set-up, are...
Uploaded on: April 14, 2023