LANDES-CHATEAU , Cassandre

IMPORTANCE Radiologically isolated syndrome (RIS) represents the earliest detectable preclinical phase of multiple sclerosis (MS) punctuated by incidental magnetic resonance imaging (MRI) white matter anomalies within the central nervous system.OBJECTIVE To determine the time to onset of symptoms consistent with MS.DESIGN, SETTING, AND...

Radiologically Isolated Syndrome (RIS) is the pre-clinical phase of multiple sclerosis (MS). It corresponds to the incidental discovery of white matter abnormalities suggestive of MS based on their location, size, and shape on Magnetic Resonance Imaging (MRI) performed for a reason other than for suspicion of demyelinating disease in subjects...

Background: Previous studies have shown that people with multiple sclerosis (MS) had frequent healthcare visits up to 10 years before being diagnosed but with no information from magnetic resonance imaging (MRI) scans of the connection with the radiologically isolated syndrome (RIS).Objective: To analyze healthcare use 3 years before the RIS...

Introduction: Nowadays, mandatory vaccination in patients with multiple sclerosis (MS) is widely recommended. Regarding COVID19, the absence of specific warnings led to the proposal of vaccination in patients with inflammatory diseases of the central nervous system. However global vaccination hesitancy remains and potential effect of COVID19...

Background: Vaccination in patients with multiple sclerosis (MS) treated with immunosuppressive drugs is highly recommended. Regarding COVID-19 vaccination, no specific concern has been raised. Objectives: We aimed to evaluate if COVID-19 vaccination or infection increased the risk of disease activity, either radiological or clinical, with...