The term diaschisis refers to a neural dysfunction manifesting in anatomically intact, but functionally related, brain regions distant from a primary lesion. Here we report the diaschisis phenomenon as a consequence of a first demyelinating event in the middle and superior cerebellar peduncles in both the ipsilateral cerebellar hemisphere and...
-
2019 (v1)PublicationUploaded on: April 14, 2023
-
2019 (v1)Publication
Background: People with multiple sclerosis (PwMS) report impaired hand movements and coordination. With an engineered glove we demonstrated altered finger movements in PwMS; increasing age resulted in decreased performance in healthy subjects (normative data). This study aims at investigating aging effects on finger motor performance in PwMS,...
Uploaded on: April 14, 2023 -
2023 (v1)Publication
: Soma and neurite density image (SANDI) is an advanced diffusion magnetic resonance imaging biophysical signal model devised to probe in vivo microstructural information in the gray matter (GM). This model requires acquisitions that include b values that are at least six times higher than those used in clinical practice. Such high b values are...
Uploaded on: February 14, 2024 -
2023 (v1)Publication
The central vein sign (CVS) has been proposed as a biomarker of multiple sclerosis (MS). In adult-onset MS (AOMS), 40%-threshold of CVS positive (+) lesions demonstrated high accuracy for MS diagnosis. However, CVS+ lesions' performance has not been characterized in paediatric-onset (POMS) yet. We compared the CVS contribution to MS diagnosis...
Uploaded on: February 7, 2024 -
2022 (v1)Publication
In multiple sclerosis, the correlation between white matter lesion volumes (LV) and expanded disability status scale (EDSS) is at best moderate, leading to the "clinico-radiological paradox", influenced by many factors, including the lack of information on the spatial localisation of each lesion on synthetic metrics such as LV. We used a...
Uploaded on: February 4, 2024 -
2022 (v1)Publication
Vaccines prevent infections in patients with multiple sclerosis (MS). Though recommendations regarding vaccinating patients with MS have been recently published, real-world data regarding vaccines' planning in patients receiving disease-modifying drugs (DMDs) for MS are missing. Our aim was, therefore, to describe vaccination coverage rates,...
Uploaded on: February 14, 2024 -
2019 (v1)Publication
ObjectiveTo investigate whether inner nuclear layer (INL) thickness as assessed with optical coherence tomography differs between patients with progressive MS (P-MS) according to age and disease activity.MethodsIn this retrospective longitudinal analysis, differences in terms of peripapillary retinal nerve fiber layer (pRNFL), ganglion cell...
Uploaded on: March 27, 2023 -
2023 (v1)Publication
Background and PurposeChimeric antigen receptor (CAR) T-cell therapy is potentially associated with treatment-related toxicities mainly consisting of cytokine release syndrome (CRS) and immune-effector cell-associated neurotoxicity syndrome (ICANS). We evaluated brain metabolic correlates of CRS with and without ICANS in diffuse large B-cell...
Uploaded on: February 11, 2024 -
2022 (v1)Publication
Background: Treatment with fingolimod for multiple sclerosis (MS) reduces the efficacy of COVID-19 vaccination. The aim of this exploratory study was to evaluate whether main lymphocyte subsets and demographic features correlated to the subsequent increase in anti-SARS-CoV2 antibodies following the third dose of COVID-19 vaccination in...
Uploaded on: January 31, 2024 -
2024 (v1)Publication
Background: Although apathy has been associated with fronto-striatal dysfunction in several neurological disorders, its clinical and magnetic resonance imaging (MRI) correlates have been poorly investigated in people with multiple sclerosis (PwMS).Objectives: To evaluate clinical variables and investigate microstructural integrity of...
Uploaded on: July 3, 2024 -
2023 (v1)Publication
IntroductionThe subventricular zone (SVZ) represents one of the main adult brain neurogenesis niche. In-vivo imaging of SVZ is very challenging and little is known about MRI correlates of SVZ macro- and micro-structural injury in multiple sclerosis (MS) patients. MethodsThe aim of the present study is to evaluate differences in terms of volume...
Uploaded on: February 14, 2024 -
2021 (v1)Publication
Background: Defining immune mechanisms leading to multiple sclerosis (MS) is difficult, due to the great inter-individual difference in immune system responses. The anti-CD52 antibody alemtuzumab transiently abolishes differences in immune parameters among individuals, allowing analysis of subsequent immune cell repopulation patterns, and their...
Uploaded on: April 14, 2023 -
2019 (v1)Publication
Background: Brain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the field of MS. In fact, MS is a complex disease and several processes can be selected as a target for PET imaging. The use...
Uploaded on: April 14, 2023 -
2019 (v1)Publication
Objective To evaluate in clinically isolated syndrome (CIS) and migraine with aura (MA) how the number of periventricular lesions (PVLs) detected at MRI influences diagnostic performance when the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) or the 2017 revised criteria are applied. Methods In this retrospective study, white matter...
Uploaded on: April 14, 2023 -
2019 (v1)Publication
Objective To analyze MRI images in patients with MS who experienced worsening of neurologic status (WNS) after stopping fingolimod (FTY).MethodsIn this retrospective study, demographic, clinical, and radiologic data of patients with MS who experienced WNS after stopping FTY were retrospectively collected. We introduced the "δExpanded Disability...
Uploaded on: April 14, 2023 -
2020 (v1)Publication
The importance of upper limb function in multiple sclerosis (MS) is increasingly recognized, especially for evaluating progressive patients with a reduced mobility. Two sensor-engineered gloves able to quantitatively measure the timing of finger opposition movements was previously used to assess upper limb disability in MS. Aims of the study...
Uploaded on: April 14, 2023 -
2020 (v1)Publication
Abstract BACKGROUND: Assessment of nigrostriatal degeneration is a key element to discriminate between dementia with Lewy bodies (DLB) and Alzheimer disease (AD), and it is often evaluated using ioflupane (123I-FP-CIT) single-photon emission computed tomography (SPECT). Given the limited availability of 123I-FP-CIT SPECT, we evaluated if a...
Uploaded on: April 14, 2023 -
2020 (v1)Publication
The clinical construct of mild cognitive impairment (MCI) identifies a syndrome of cognitive deficit which is not significant enough to interfere with daily activities, whose fate is unpredictable without establishing the underlying cause. Thus, MCI, though being the natural "reservoir" of subsequent dementing neurodegenerative diseases, can be...
Uploaded on: April 14, 2023 -
2021 (v1)Publication
No description
Uploaded on: November 25, 2023 -
2019 (v1)Publication
Background: A high reactivation of multiple sclerosis (MS) was reported in patients treated with alemtuzumab after fingolimod. We aimed to understand whether this shift enhanced the risk for reactivation in a real-life cohort. Methods: Subjects with relapsing MS, shifting from fingolimod to alemtuzumab were enrolled. We collected the following...
Uploaded on: April 14, 2023 -
2020 (v1)Publication
OBJECTIVE: To establish cytometry profiles associated with disease stages and immunotherapy in MS. METHODS: Demographic/clinical data and peripheral blood samples were collected from 227 patients with MS and 82 sex- and age-matched healthy controls (HCs) enrolled in a cross-sectional study at 4 European MS centers (Spain, Italy, Germany, and...
Uploaded on: March 27, 2023 -
2023 (v1)Publication
Background: Cortical multiple sclerosis lesions are clinically relevant but inconspicuous at conventional clinical MRI. Double inversion recovery (DIR) and phase-sensitive inversion recovery (PSIR) are more sensitive but often unavailable. In the past 2 years, artificial intelligence (AI) was used to generate DIR and PSIR from standard clinical...
Uploaded on: February 11, 2024