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LARSEN , Martin

Last name: LARSEN

First name: Martin

July 5, 2023 (v1)

Journal article

Metadata-only

Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Urizar, Adriana Ibarra Prause, Michala Ingerslev, Lars Roed

Summary Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Langerhans from individuals with diabetes and acts as an inhibitor of beta cell function...

Uploaded on: November 30, 2023