The recently published phase II prospective SWITCH trial evaluated whether patients with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone acetate could benefit from a 'steroid switch' from prednisone to dexamethasone. A total of 26 patients, both chemonaive (14 patients) or pretreated with docetaxel (12...
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2019 (v1)PublicationUploaded on: April 14, 2023
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2020 (v1)Publication
The novel coronavirus disease 2019 (COVID-19) shows a wide spectrum of clinical presentations, severity, and fatality rates. The reason older patients and males show increased risk of severe disease and death remains uncertain. Sex hormones, such as estradiol, progesterone, and testosterone, might be implicated in the age-dependent and...
Uploaded on: April 14, 2023 -
2020 (v1)Publication
The treatment landscape of metastatic renal cell carcinoma (mRCC), a chemotherapy-resistant disease, has dramatically changed in the last decade after the introduction of small molecule inhibitors targeting the vascular endothelial growth factor receptor and mammalian target of rapamycin kinases. The CheckMate 025 phase III trial in second line...
Uploaded on: March 27, 2023 -
2019 (v1)Publication
Small-cell carcinoma of the bladder (SCCB) is a rare, highly aggressive, neoplasm. We retrospectively analyzed the Surveillance, Epidemiology, and End Results (SEER) database to investigate the impact of chemotherapy, surgery, and radiotherapy on overall survival (OS) of patients with non-metastatic SCCB.
Uploaded on: April 14, 2023 -
2018 (v1)Publication
We retrospectively investigated the prognostic significance of periostin, an extracellular matrix protein, in tumor biopsy samples of 215 patients with prostate cancer. We found that periostin expression can predict the outcome of specific subgroups of patients. In addition to the prostate-specific antigen level and/or Gleason score, the...
Uploaded on: April 14, 2023 -
2018 (v1)Publication
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Uploaded on: April 14, 2023 -
2023 (v1)Publication
Introduction: Breast cancer is the most commonly diagnosed malignancy during pregnancy. Breast cancer during pregnancy is a challenging clinical condition requiring proper and timely multidisciplinary management. Areas covered: This review focuses on the management of breast cancer during pregnancy with a focus about the current...
Uploaded on: September 11, 2024 -
2024 (v1)Publication
Objectives To better understand the type of care offered to Italian patients with advanced breast cancer at the End-of-Life (EoL), we conducted a retrospective observational study. EoL was defined as the period of six months before death.Methods One hundred and twenty-one patients with advanced breast cancer (ABC) treated at IRCCS San Martino...
Uploaded on: July 6, 2024 -
2024 (v1)Publication
Background: Most premenopausal patients with early breast cancer (eBC) are diagnosed with hormone receptorpositive disease and therefore candidate for adjuvant endocrine therapy (ET). Patients and methods: The Gruppo Italiano Mammella (GIM) 23-POSTER (GIM23) is a multicenter, prospective, observational study conducted in 26 Italian...
Uploaded on: August 15, 2024