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LATORRE , Elisa

Last name: LATORRE

First name: Elisa

2016 (v1)

Publication

Metadata-only

The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level

Thongon, Natthakan Castiglioni, Ilaria Zucal, Chiara

The Yes-associated protein, YAP, is a transcriptional co-activator, mediating the Epithelial to Mesenchymal Transition program in pancreatic ductal adenocarcinoma (PDAC). With the aim to identify compounds that can specifically modulate YAP functionality in PDAC cell lines, we performed a small scale, drug-based screening experiment using YAP...

Uploaded on: March 27, 2023
2015 (v1)

Publication

Metadata-only

The 5'-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

Bisio, Alessandra Latorre, Elisa ANDREOTTI, VIRGINIA

CDKN2A/p16INK4a is an essential tumor suppressor gene that controls cell cycle progression and replicative senescence. It is also the main melanoma susceptibility gene. Here we report that p16INK4a 5'UTR mRNA acts as a cellular Internal Ribosome Entry Site (IRES). The potential for p16INK4a 5'UTR to drive cap-independent translation was...

Uploaded on: April 14, 2023