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LEFEBVRE , Jonathan

Last name: LEFEBVRE

First name: Jonathan

July 31, 2015 (v1)

Journal article

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Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.

Lefebvre, Jonathan Clarkson, Michael Massa, Filippo

The Wilms' tumor suppressor WT1 is a key regulator of podocyte function that is mutated in Denys-Drash and Frasier syndromes. Here we have used an integrative approach employing ChIP, exon array, and genetic analyses in mice to address general and isoform-specific functions of WT1 in podocyte differentiation. Analysis of ChIP-Seq data showed...

Uploaded on: February 28, 2023
October 8, 2021 (v1)

Journal article

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Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction

da Silva, Fabio Jian Motamedi, Fariba Weerasinghe Arachchige, Lahiru Chamara

Retinoic acid (RA) is an essential signaling molecule for cardiac development and plays a protective role in the heart after myocardial infarction (MI). In both cases, the effect of RA signaling on cardiomyocytes, the principle cell type of the heart, has been reported to be indirect. Here we have developed an inducible murine transgenic...

Uploaded on: December 3, 2022