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LENA , Gersande

Last name: LENA

First name: Gersande

November 16, 2006 (v1)

Journal article

Metadata-only

In silico-guided target identification of a scaffold-focused library: 1,3,5-triazepan-2,6-diones as novel phospholipase A2 inhibitors.

Muller, Pascal Lena, Gersande Boilard, Eric

A collection of 2150 druggable active sites from the Protein Data Bank was screened by high-throughput docking to identify putative targets for five representative molecules of a combinatorial library sharing a 1,3,5-triazepan-2,6-dione scaffold. Five targets were prioritized for experimental evaluation by computing enrichment in individual...

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