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LENAIN , Christelle

Last name: LENAIN

First name: Christelle

July 2010 (v1)

Journal article

Metadata-only

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

Ye, Jing Lenain, Christelle Bauwens, Serge

Human telomeres are protected from DNA damage by a nucleoprotein complex that includes the repeat-binding factor TRF2. Here, we report that TRF2 regulates the 5′ exonuclease activity of its binding partner, Apollo, a member of the metallo-β-lactamase family that is required for telomere integrity during S phase. TRF2 and Apollo also suppress...

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