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LIGRESTI , Alessia

Last name: LIGRESTI

First name: Alessia

2016 (v1)

Publication

Metadata-only

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

Brindisi, Margherita Maramai, Samuele Gemma, Sandra

We report the discovery of compound 4a, a potent β-lactam-based monoacylglycerol lipase (MGL) inhibitor characterized by an irreversible and stereoselective mechanism of action, high membrane permeability, high brain penetration evaluated using a human in vitro blood−brain barrier model, high selectivity in binding and affinity-based proteomic...

Uploaded on: April 14, 2023