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LIMA , Michelle De Souza

Last name: LIMA

First name: Michelle De Souza

May 2021 (v1)

Journal article

Metadata-only

Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

Manuel, Raoul Lima, Michelle de Souza Dilly, Sébastien

Specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS), two enzymes associated with redox stress in tumor cells, has aroused great pharmacological interest. Here, we show how these enzymes distinguish between isomeric 2'- and 3'-phosphate derivatives, a difference used to improve the specificity of inhibition by isolated 2'- and...

Uploaded on: December 4, 2022