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LITMAN , Thomas

Last name: LITMAN

First name: Thomas

August 30, 2021 (v1)

Publication

Metadata-only

R-Loop–Mediated ssDNA Breaks Accumulate following Short-Term Exposure to the HDAC Inhibitor Romidepsin

Safari, Maryam Litman, Thomas Robey, Robert W.

Histone deacetylase inhibitors (HDACi) induce hyperacetylation of histones by blocking HDAC catalytic sites. Despite regulatory approvals in hematological malignancies, limited solid tumor clinical activity has constrained their potential, arguing for better understanding of mechanisms of action (MOA). Multiple activities of HDACis have been...

Uploaded on: December 4, 2022