Human eosinophils represent approximately 1% of peripheral blood leukocytes. However, these cells have the propensity to leave the blood stream and migrate into inflamed tissues. Eosinophilic inflammation is present in a significant proportion of patients with severe asthma. Asthma is a chronic inflammatory disorder that affects more than 315...
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2017 (v1)PublicationUploaded on: April 14, 2023
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April 19, 2017 (v1)Journal article
International audience
Uploaded on: December 3, 2022 -
May 1, 2010 (v1)Journal article
Angiogenesis and lymphangiogenesis mediated by vascular endothelial growth factors (VEGFs) are main features of chronic inflammation and tumors. Secreted phospholipases A(2) (sPLA(2)s) are overexpressed in inflammatory lung diseases and cancer and they activate inflammatory cells by enzymatic and receptor-mediated mechanisms. We investigated...
Uploaded on: December 3, 2022 -
November 17, 2022 (v1)Journal article
Abstract High levels of human group IIA secreted phospholipase A 2 (hGIIA) have been associated with various inflammatory disease conditions. We have recently shown that hGIIA activity and concentration are increased in the plasma of patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) and negatively correlate with...
Uploaded on: December 3, 2022 -
July 23, 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022