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LOPEZ-MEJIA , Isabel C

Last name: LOPEZ-MEJIA

First name: Isabel C

July 15, 2013 (v1)

Journal article

Metadata-only

Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

Lopez-Mejia, Isabel C de Toledo, Marion Chavey, Carine

Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing support for the involvement of LMNA processing in pathological aging. Lamin C expression is...

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