LUQUE LAÓ , María Ángeles

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El sistema nervioso motor se organiza de forma jerárquica y modular para codificar el movimiento. El sistema de generación de los movimientos oculares sacádicos permite estudiar los mecanismos de programación y ejecución del movimiento a diferentes niveles. La red neuronal que genera estos movimientos ha sido ampliamente estudiada en mamíferos,...

Fragile X syndrome (FXS) is caused by a failure of neuronal cells to express the gene encoding the fragile mental retardation protein (FMRP). Clinical features of the syndrome include intellectual disability, learning impairment, hyperactivity, seizures and anxiety. Fmr1 knockout (KO) mice do not express FMRP and, as a result, reproduce some...

The mammalian oculomotor nucleus receives a strong γ-aminobutyric acid (GABA)ergic synaptic input, whereas such projections have rarely been reported in fish. In order to determine whether this synaptic organization is preserved across vertebrates, we investigated the GABAergic projections to the oculomotor nucleus in the goldfish by combining...