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MÉLIK PARSADANIANTZ , S.

Last name: MÉLIK PARSADANIANTZ

First name: S.

July 30, 2008 (v1)

Journal article

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Stromal-cell-derived factor 1alpha /CXCL12 modulates high-threshold calcium currents in rat substantia nigra.

Guyon, Alice Skrzydelski, D. Rovère, C.

Dopaminergic neurons of the substantia nigra constitutively express the CXCR4 receptor for the chemokine stromal-cell-derived factor 1alpha (CXCL12) but, to date, no direct effect of CXCR4 activation by CXCL12 on membrane conductance of dopaminergic neurons has been demonstrated. We tested the effects of CXCL12 on whole-cell currents of...

Uploaded on: December 4, 2022
September 15, 2009 (v1)

Journal article

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Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release.

Guyon, A. Skrzydelski, D. de Giry, I.

Accumulating evidence show that chemokines can modulate the activity of neurons through various mechanisms. Recently, we demonstrated that CCR2, the main receptor for the chemokine CCL2, is constitutively expressed in dopamine neurons in the rat substantia nigra. Here we show that unilateral intranigral injections of CCL2 (50 ng) in freely...

Uploaded on: December 3, 2022