Doppel (Dpl) shares common structural features with the prion protein (PrP) whose pathologic isoform is considered as the causative agent of prion diseases. Although their physiological functions in the immune system remain largely unknown, we demonstrated that substantial amounts of PrP and Dpl are expressed by spleen cells notably B...
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August 2008 (v1)Journal articleUploaded on: December 4, 2022
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2012 (v1)Journal article
The prion protein (PrP) is absolutely required for the development of prion diseases; nevertheless, its physiological functions in the central nervous system remain elusive. Using a combination of behavioral, electrophysiological and biochemical approaches in transgenic mouse models, we provide strong evidence for a crucial role of PrP in...
Uploaded on: December 4, 2022 -
April 20, 2012 (v1)Journal article
International audience
Uploaded on: December 4, 2022