MARIANI , Marcello

A TDM-guided anti-infective therapy especially in the most complex clinical situations and/or in presence of antibiotic resistant pathogens should be started in order to personalize therapy. The possibility of evaluating plasma concentrations of antibiotics in pediatric patients, especially in the most complex clinical conditions, can have...

Mutations of the COPA gene cause an immune dysregulatory disease characterised by polyarticular arthritis and progressive interstitial lung disease with pulmonary haemorrhages. We report the case of a young girl that presented at age 3 with polyarticular arthritis, chronic cough and high titer rheumatoid factor. Radiologic imaging showed...