1997 (v1)
Publication
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2007 (v1)Publication
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2005 (v1)Publication
Guidelines for genotoxicity testing of pharmaceuticals1 establish that specific protocol modifications or additional tests are necessary for the best possible detection of genotoxicity of compounds with specific structural alerts. However, they do not show the need for doing adequate tests in order to assess whether a nitrosatable drug could...
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1992 (v1)Publication
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2004 (v1)Publication
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2003 (v1)Publication
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1993 (v1)Publication
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1990 (v1)Publication
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2003 (v1)Publication
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2000 (v1)Publication
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2006 (v1)Publication
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2012 (v1)Publication
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2009 (v1)Publication
This survey is a compendium of genotoxicity and carcinogenicity information of 838 marketed drugs, whose expected clinical use is continuous for at least 6 months or intermittent over an extended period of time. Of these 838 drugs, 366 (43.7%) do not have retrievable genotoxicity or carcinogenicity data. The remaining 472 (56.3%) have at least...
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2009 (v1)Publication
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2002 (v1)Publication
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1997 (v1)Publication
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1987 (v1)Publication
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2005 (v1)Publication
In the last 30 years, countless studies have shown that antihypertensive drug therapy substantially reduces the risk of hypertension-related morbidity and mortality. However, the optimal choice for initial pharmacotherapy of hypertension is still controversial. The guidelines for hypertension management agree on many items but differ on a very...
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1989 (v1)Publication
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2001 (v1)Publication
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2007 (v1)Publication
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2005 (v1)Publication
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2009 (v1)Publication
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1995 (v1)Publication
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Uploaded on: March 27, 2023